Activation of JAK-STAT signaling is one of the hallmarks of myelofibrosis, a
myeloproliferative neoplasm that leads to inflammation, progressive bone marrow failure …

Inflammatory and oncogenic signaling, both known to challenge genome stability, are key
drivers of BCR-ABL-positive chronic myeloid leukemia (CML) and JAK2 V617F-positive …

Monoclonal antibodies (Abs) that recognize major histocompatability complex (MHC)-
presented tumor antigens in a manner similar to T cell receptors (TCRs) have great potential …

Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes
thrombocytopenia 2 (THC2), an inherited platelet disorder associated with a predisposition …

As caretakers of the hematopoietic system, hematopoietic stem cells assure a lifelong supply
of differentiated populations that are responsible for critical bodily functions, including …

Members of the Janus family of nonreceptor tyrosine kinases (JAK1, JAK2, JAK3, and TYK2)
transmit a diversity of ligand-mediated signals, from cytokines and hormones, resulting in …

N-glycan-mediated activation of the thrombopoietin receptor (MPL) under pathological
conditions has been implicated in myeloproliferative neoplasms induced by mutant …

Abstract Protein Kinase‐Like Non‐Kinases (PKLNKs), commonly known as
“pseudokinases”, are homologous to eukaryotic Ser/Thr/Tyr protein kinases (PKs) but lack …

Progress in the identification of core multi-protein modules within JAK/STAT pathway has
enabled researchers to develop a better understanding of the linchpin role of deregulated …

Thrombopoietin (THPO or TPO) is an essential cytokine for hematopoietic stem cell (HSC)
maintenance and megakaryocyte differentiation. Here, we report the 3.4 Aresolution …