Thrombopoietin (THPO) and its receptor myeloproliferative leukemia virus oncogene (MPL)
regulate hematopoietic stem cell (HSC) quiescence and maintenance, but also …

Many membrane proteins utilize dimerization to transmit signals across the cell membrane
via regulation of the lateral binding affinity. The complexity of natural membrane proteins …

The interplay and communication between cells build the foundation of life. Many signaling
processes at the cell surface and inside the cell, as well as the cellular function itself …

The conserved Wnt signaling has been classified as two categories of canonical and
noncanonical Wnt signaling. With a high promiscuity of Wnt signaling, how receptors from …

Our understanding of the biological role of the βc family of cytokines has evolved
enormously since their initial identification as bone marrow colony stimulating factors in the …

JAK/STAT 信号通路参与细胞的生长, 分化, 凋亡和免疫调节等重要的生物学过程,
是细胞因子介导的最重要的信号转导途径之一. 在昆虫中, JAK/STAT 是一条相对保守的信号 …

Simple Summary Myeloproliferative neoplasms are a group of rare disorders characterized
by genetic mutations in hematopoietic stem cells and by the presence of systemic …

Pharmacological Sciences OPEN ACCESS agents under a defined set of rules and is well
suited for simulation of biological systems whose properties are usually only partially known …

Growth hormone (GH) receptor (GHR) and prolactin (PRL) receptor (PRLR) are
transmembrane class I cytokine receptors that co-exist in various normal and cancerous …

Promiscuous binding of different Janus kinases (JAKs) to class I/II cytokine receptors has
been reported, yet its role in signaling is unclear. To systematically explore JAK pairing in …