Superparamagnetic iron oxide nanoparticles for magnetic hyperthermia: Recent advancements, molecular effects, and future directions in the omics era

C Pucci, A Degl'Innocenti, MB Gümüş… - Biomaterials Science, 2022 - pubs.rsc.org
Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted attention in the
biomedical field thanks to their ability to prompt hyperthermia in response to an alternated …

Advanced strategies for overcoming endosomal/lysosomal barrier in nanodrug delivery

C Qiu, F Xia, J Zhang, Q Shi, Y Meng, C Wang, H Pang… - Research, 2023 - spj.science.org
Nanocarriers have therapeutic potential to facilitate drug delivery, including biological
agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by …

Bacteria loaded with glucose polymer and photosensitive ICG silicon-nanoparticles for glioblastoma photothermal immunotherapy

R Sun, M Liu, J Lu, B Chu, Y Yang, B Song… - Nature …, 2022 - nature.com
Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …

Drug-loaded lipid magnetic nanoparticles for combined local hyperthermia and chemotherapy against glioblastoma multiforme

L Beola, N Iturrioz-Rodríguez, C Pucci, R Bertorelli… - ACS …, 2023 - ACS Publications
Glioblastoma multiforme (GBM) is a devastating tumor of the central nervous system,
currently missing an effective treatment. The therapeutic gold standard consists of surgical …

Non-apoptotic cell death-based cancer therapy: Molecular mechanism, pharmacological modulators, and nanomedicine

X Wang, P Hua, C He, M Chen - Acta Pharmaceutica Sinica B, 2022 - Elsevier
As an emerging cancer therapeutic target, non-apoptotic cell death such as ferroptosis,
necroptosis and pyroptosis, etc., has revealed significant potential in cancer treatment for …

Micro‐nanocarriers based drug delivery technology for blood‐brain barrier crossing and brain tumor targeting therapy

L Wang, Y Shi, J Jiang, C Li, H Zhang, X Zhang… - Small, 2022 - Wiley Online Library
The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

Nanotechnology and nanocarrier-based drug delivery as the potential therapeutic strategy for glioblastoma multiforme: An update

JF Hsu, SM Chu, CC Liao, CJ Wang, YS Wang, MY Lai… - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma multiforme (GBM) are among the most lethal tumors. The
highly invasive nature and presence of GBM stem cells, as well as the blood brain barrier …

Magnetic self-assembly of 3D multicellular microscaffolds: A biomimetic brain tumor-on-a-chip for drug delivery and selectivity testing

A Marino, M Battaglini, A Carmignani, F Pignatelli… - APL …, 2023 - pubs.aip.org
In recent years, the need for highly predictive brain cancer models to test new anticancer
compounds and experimental therapeutic approaches has significantly increased. Realistic …

[HTML][HTML] Ultrasound-responsive nutlin-loaded nanoparticles for combined chemotherapy and piezoelectric treatment of glioblastoma cells

C Pucci, A Marino, Ö Şen, D De Pasquale, M Bartolucci… - Acta biomaterialia, 2022 - Elsevier
Glioblastoma multiforme (GBM), also known as grade IV astrocytoma, represents the most
aggressive primary brain tumor. The complex genetic heterogeneity, the acquired drug …

Multifunctional nanozyme for multimodal imaging-guided enhanced sonodynamic therapy by regulating the tumor microenvironment

S Liu, W Zhang, Q Chen, J Hou, J Wang, Y Zhong… - Nanoscale, 2021 - pubs.rsc.org
Sonodynamic therapy (SDT) is a highly promising approach for cancer therapy, but its
efficacy is severely hampered by the low specificity of sonosensitizers and the unfavorable …