Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Simple Summary Inflammation is assessed as a hallmark of cancer and it is now widely
recognized that there exists a direct causal link between inflammation and tumors. Among …

Eicosanoids represent a family of active biolipids derived from arachidonic acid primarily
through the action of cytosolic phospholipase A2-α. Three major downstream pathways …

Cancer therapy is a double-edged sword, as surgery and chemotherapy can induce an
inflammatory/immunosuppressive injury response that promotes dormancy escape and …

The clinical application of immunotherapy is the milestone of cancer treatment. However,
some patients have bad reaction. Cyclooxygenase-2 (COX-2) is frequently expressed in …

Elevated expression of COX‐2 and increased levels of PGE2 are found in numerous
cancers and are associated with tumour development and progression. Although …

While chemotherapy provides useful palliation, advanced lung cancer remains incurable
since those tumors that are initially sensitive to therapy rapidly develop acquired resistance …

Cancer immunotherapy has been predominantly focused on biologically based intervention
strategies. However, recent advances in the understanding of tumour–host interactions at …

BACKGROUND. Nuclear factor‐κB (NF‐κB), a key transcription factor thought to play a
major role in carcinogenesis, regulates many important signaling pathways involved in …

The status of a host's immune response influences both the development and progression of
a malignancy such that immune responses can have both pro-and anti-tumorigenic effects …