The re-emergence of natural products for drug discovery in the genomics era

AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

[HTML][HTML] Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential

S Agrawal, D Acharya, A Adholeya… - Frontiers in …, 2017 - frontiersin.org
Marine environments are largely unexplored and can be a source of new molecules for the
treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine …

[HTML][HTML] Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology

MC Wilson, J Piel - Chemistry & biology, 2013 - cell.com
Most biologically active microbial natural products are known from strains that can be
isolated and cultivated in the laboratory. However, the genomics era has revealed that …

[图书][B] Current trends in microbial biotechnology for sustainable agriculture

AN Yadav, J Singh, C Singh, N Yadav - 2021 - Springer
Microbial biotechnology is an emerging field with greater applications in diverse sectors
involving food security, human nutrition, plant protection, and overall basic research in the …

[HTML][HTML] Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites

R Chávez, F Fierro, RO García-Rico… - Frontiers in Microbiology, 2015 - frontiersin.org
Natural product search is undergoing resurgence upon the discovery of a huge previously
unknown potential for secondary metabolite (SM) production hidden in microbial genomes …

[HTML][HTML] Actinomycete-derived polyketides as a source of antibiotics and lead structures for the development of new antimicrobial drugs

HL Robertsen, EM Musiol-Kroll - Antibiotics, 2019 - mdpi.com
Actinomycetes are remarkable producers of compounds essential for human and veterinary
medicine as well as for agriculture. The genomes of those microorganisms possess several …

Antimicrobials, drug discovery, and genome mining

RJ Scheffler, S Colmer, H Tynan, AL Demain… - Applied microbiology …, 2013 - Springer
Over the years, antibiotics have provided an effective treatment for a number of microbial
diseases. However recently, there has been an increase in resistant microorganisms that …

Eco-friendly biopesticides derived from CO2-Fixing cyanobacteria

NR Akmukhanova, YK Leong, SN Seiilbek… - Environmental …, 2023 - Elsevier
There is currently an escalating global demand for the utilization of plant and natural extracts
as pesticides due to their minimal health risks. Cyanobacteria are highly valuable organisms …

[HTML][HTML] Antimicrobial peptides from marine proteobacteria

F Desriac, C Jégou, E Balnois, B Brillet, P Le Chevalier… - Marine drugs, 2013 - mdpi.com
After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the
efficiency of “classical” antibiotics has decreased significantly. New drugs to fight MDR …

From genome mining to phenotypic microarrays: Planctomycetes as source for novel bioactive molecules

O Jeske, M Jogler, J Petersen, J Sikorski… - Antonie Van …, 2013 - Springer
Most members of the phylum Planctomycetes share many unusual traits that are unique for
bacteria, since they divide independent of FtsZ through asymmetric budding, possess a …