The re-emergence of natural products for drug discovery in the genomics era
AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …
use has diminished in the past two decades, in part because of technical barriers to …
[HTML][HTML] Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential
S Agrawal, D Acharya, A Adholeya… - Frontiers in …, 2017 - frontiersin.org
Marine environments are largely unexplored and can be a source of new molecules for the
treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine …
treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine …
[HTML][HTML] Metagenomic approaches for exploiting uncultivated bacteria as a resource for novel biosynthetic enzymology
MC Wilson, J Piel - Chemistry & biology, 2013 - cell.com
Most biologically active microbial natural products are known from strains that can be
isolated and cultivated in the laboratory. However, the genomics era has revealed that …
isolated and cultivated in the laboratory. However, the genomics era has revealed that …
[图书][B] Current trends in microbial biotechnology for sustainable agriculture
Microbial biotechnology is an emerging field with greater applications in diverse sectors
involving food security, human nutrition, plant protection, and overall basic research in the …
involving food security, human nutrition, plant protection, and overall basic research in the …
[HTML][HTML] Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites
Natural product search is undergoing resurgence upon the discovery of a huge previously
unknown potential for secondary metabolite (SM) production hidden in microbial genomes …
unknown potential for secondary metabolite (SM) production hidden in microbial genomes …
[HTML][HTML] Actinomycete-derived polyketides as a source of antibiotics and lead structures for the development of new antimicrobial drugs
HL Robertsen, EM Musiol-Kroll - Antibiotics, 2019 - mdpi.com
Actinomycetes are remarkable producers of compounds essential for human and veterinary
medicine as well as for agriculture. The genomes of those microorganisms possess several …
medicine as well as for agriculture. The genomes of those microorganisms possess several …
Antimicrobials, drug discovery, and genome mining
RJ Scheffler, S Colmer, H Tynan, AL Demain… - Applied microbiology …, 2013 - Springer
Over the years, antibiotics have provided an effective treatment for a number of microbial
diseases. However recently, there has been an increase in resistant microorganisms that …
diseases. However recently, there has been an increase in resistant microorganisms that …
Eco-friendly biopesticides derived from CO2-Fixing cyanobacteria
NR Akmukhanova, YK Leong, SN Seiilbek… - Environmental …, 2023 - Elsevier
There is currently an escalating global demand for the utilization of plant and natural extracts
as pesticides due to their minimal health risks. Cyanobacteria are highly valuable organisms …
as pesticides due to their minimal health risks. Cyanobacteria are highly valuable organisms …
[HTML][HTML] Antimicrobial peptides from marine proteobacteria
After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the
efficiency of “classical” antibiotics has decreased significantly. New drugs to fight MDR …
efficiency of “classical” antibiotics has decreased significantly. New drugs to fight MDR …
From genome mining to phenotypic microarrays: Planctomycetes as source for novel bioactive molecules
O Jeske, M Jogler, J Petersen, J Sikorski… - Antonie Van …, 2013 - Springer
Most members of the phylum Planctomycetes share many unusual traits that are unique for
bacteria, since they divide independent of FtsZ through asymmetric budding, possess a …
bacteria, since they divide independent of FtsZ through asymmetric budding, possess a …