Targeting lactate-related cell cycle activities for cancer therapy
J Lin, G Liu, L Chen, HF Kwok, Y Lin - Seminars in cancer biology, 2022 - Elsevier
Lactate has long been considered as a metabolic by-product of aerobic glycolysis for
cancer. However, more and more studies have shown that lactate can regulate cancer …
cancer. However, more and more studies have shown that lactate can regulate cancer …
Evodiamine as an anticancer agent: a comprehensive review on its therapeutic application, pharmacokinetic, toxicity, and metabolism in various cancers
Evodiamine is a major alkaloid component found in the fruit of Evodia rutaecarpa. It shows
the anti-proliferative potential against a wide range of cancers by suppressing cell growth …
the anti-proliferative potential against a wide range of cancers by suppressing cell growth …
Hypoxia‐stimulated ATM activation regulates autophagy‐associated exosome release from cancer‐associated fibroblasts to promote cancer cell invasion
L Xi, M Peng, S Liu, Y Liu, X Wan, Y Hou… - Journal of …, 2021 - Wiley Online Library
Cancer‐associated fibroblasts (CAFs) as a predominant cell component in the tumour
microenvironment (TME) play an essential role in tumour progression. Our earlier studies …
microenvironment (TME) play an essential role in tumour progression. Our earlier studies …
The tumor immune microenvironment in pancreatic ductal adenocarcinoma: Neither hot nor cold
Simple Summary In this review, we discuss the current understanding of pro-and anticancer
immune responses in the tumor immune microenvironment of pancreatic ductal …
immune responses in the tumor immune microenvironment of pancreatic ductal …
Six‐Membered Aromatic Nitrogen Heterocyclic Anti‐Tumor Agents: Synthesis and Applications
J Li, A Gu, XM Nong, S Zhai, ZY Yue… - The Chemical …, 2023 - Wiley Online Library
Cancer stands as a serious malady, posing substantial risks to human well‐being and
survival. This underscores the paramount necessity to explore and investigate novel …
survival. This underscores the paramount necessity to explore and investigate novel …
NF-κB and pancreatic cancer; chapter and verse
J Silke, LA O'Reilly - Cancers, 2021 - mdpi.com
Simple Summary The incidence of pancreatic cancer is increasing but there has been little
progress in the diagnosis and survival rates of this lethal cancer for decades. Understanding …
progress in the diagnosis and survival rates of this lethal cancer for decades. Understanding …
An insight into miR-1290: an oncogenic miRNA with diagnostic potential
M Guz, W Jeleniewicz, M Cybulski - International Journal of Molecular …, 2022 - mdpi.com
For more than two decades, the view of the roles of non-coding RNAs (ncRNAs) has been
radically changing. These RNA molecules that are transcribed from our genome do not have …
radically changing. These RNA molecules that are transcribed from our genome do not have …
NF-κB dependent chemokine signaling in pancreatic cancer
C Geismann, H Schäfer, JP Gundlach, C Hauser… - Cancers, 2019 - mdpi.com
Pancreatic cancer is one of the carcinomas with the worst prognoses, as shown by its five-
year survival rate of 9%. Although there have been new therapeutic innovations, the …
year survival rate of 9%. Although there have been new therapeutic innovations, the …
Network Pharmacology Combined with Bioinformatics to Investigate the Mechanisms and Molecular Targets of Astragalus Radix-Panax notoginseng Herb Pair on …
J Zhao, C Mo, W Shi, LF Meng… - … Based Complementary and …, 2021 - Wiley Online Library
Background. Astragalus Radix (AR)‐Panax notoginseng (PN), a classical herb pair, has
shown significant effects in treating diabetic nephropathy (DN). However, the intrinsic …
shown significant effects in treating diabetic nephropathy (DN). However, the intrinsic …
Metastatic transition of pancreatic ductal cell adenocarcinoma is accompanied by the emergence of pro-invasive cancer-associated fibroblasts
Simple Summary How stromal cells control tumor progression is an active area of
investigation. Cancer associated fibroblasts (CAFs) have been suggested to both limit, or …
investigation. Cancer associated fibroblasts (CAFs) have been suggested to both limit, or …