The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …

The neurohypophysial hormone arginine vasopressin (AVP) is essential for a wide range of
physiological functions, including water reabsorption, cardiovascular homeostasis, hormone …

G protein coupled receptors have historically been one of the most druggable classes of
cellular proteins. The members of this large receptor gene family couple to primary effectors …

Evidence suggests that the CXC–chemokine receptor-4 pathway plays a role in cancer cell
homing and metastasis, and thus represents a potential target for cancer therapy. The …

For cancers to develop, sustain and spread, the appropriation of key homeostatic
physiological systems that influence cell growth, migration and death, as well as …

Members of the seven-transmembrane receptor (7TMR), or G protein-coupled receptor
(GPCR), superfamily represent some of the most successful targets of modern drug therapy …

The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

There are significant numbers of nutrient sensing G protein-coupled receptors (GPCRs) that
can be found in cells of the immune system and in tissues that are involved in metabolic …

G protein-coupled receptors (GPCRs) are historically the most successful family of drug
targets. In recent times it has become clear that the pharmacology of these receptors is far …