Coenzyme Q (CoQ) is not only the single antioxidant synthesized in humans but also an
obligatory element of mitochondrial functions. We have previously reported CoQ deficiency …

Therapeutic trials of exercise training and coenzyme Q10 supplementation should continue
to be offered to patients with mitochondrial myopathies pending the results of evaluation in …

Mitochondrial dysfunction has been implicated in the pathogenesis of inflammation and
multi-organ dysfunction in major trauma, including burn injury. Coenzyme Q10 (CoQ10) is a …

Mitochondrial DNA (mtDNA) mutations, including the m. 3243A> G mutation that causes
mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), are …

CoQ is an essential electron carrier in the mitochondrial respiratory chain of both eukaryotes
and prokaryotes. It consists of a benzoquinone head group and a hydrophobic …

Abstract Primary coenzyme Q 10 (CoQ 10) deficiency is a rare mitochondrial disorder
associated with 5 major clinical phenotypes:(1) encephalomyopathy,(2) severe infantile …

Abstract Coenzyme Q10 (CoQ10) deficiency is a clinically and genetically heterogeneous
subtype of mitochondrial disease. We report two girls with ataxia and mitochondrial …

BACKGROUND: Coenzyme Q10 (CoQ10 or ubiquinone) deficiency can be due either to
mutations in genes involved in CoQ10 biosynthesis pathway, or to mutations in genes …

Purpose: Corneal involvement in mitochondrial disease is seldom described. Kearns-Sayre
syndrome (KSS) is a mitochondrial disorder characterized by retinitis pigmentosa, external …

Abstract Background The Coq protein complex assembled from several Coq proteins is
critical for coenzyme Q 6 (CoQ 6) biosynthesis in yeast. Secondary CoQ 10 deficiency is …