During the past few decades, supercritical fluid (SCF) has emerged as an effective
alternative for many traditional pharmaceutical manufacturing processes. Operating active …

Poor water solubility and poor bioavailability are problems with many pharmaceuticals.
Increasing surface area by micronization is an effective strategy to overcome these …

The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

Despite the success in developing various pharmaceutical formulations, most of the active
pharmaceutical ingredients (APIs)/drugs, according to the Biopharmaceutics Classification …

In this work, amorphous atorvastatin calcium nanoparticles were successfully prepared
using the supercritical antisolvent (SAS) process. The effect of process variables on particle …

Supercritical antisolvent precipitation (SAS) has been successfully used to micronize several
kinds of materials. A great variety of morphologies, such as nanoparticles with mean …

The objective of the study was to prepare amorphous atorvastatin hemi-calcium using spray-
drying and supercritical antisolvent (SAS) process and evaluate its physicochemical …

The review focuses on the application of supercritical fluids as antisolvents in the
pharmaceutical field and demonstrates the supercritical antisolvent method in the use of …

Supercritical antisolvent micronization has been the subject of many works aimed at the
production of precipitates with controlled particle size and morphology. Several …

In the foreseeable future, the pharmaceuticals market, nanomedicine, and healthcare
systems will largely depend on the drug nanoparticle formulation technology. Perceiving …