The role of oxidative stress in the occurrence and development of diabetes mellitus is both
critical and pivotal. Several molecular event cascade in different metabolic pathways such …

Hesperidin and hesperetin are polyphenols that can be found predominantly in citrus fruits.
They possess a variety of pharmacological properties such as neuroprotective and …

ATP-sensitive potassium channels (K ATP) couple intracellular ATP levels with membrane
excitability. These channels play crucial roles in many essential physiological processes …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Rises in local neural activity trigger local increases of cerebral blood flow, which is essential
to match local energy demands. However, the specific location of microvascular flow control …

Neurons within the central nervous system receive humoral and central (neurotransmitter or
neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent …

ATP sensitive potassium channels (KATP) are so named because they open as cellular ATP
levels fall. This leads to membrane hyperpolarization and thus links cellular metabolism to …

Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly
vulnerable to degeneration compared to other dopaminergic neurons. The age‐dependent …

Summary Melanocortin 4 receptors (MC4Rs) in the central nervous system are key
regulators of energy and glucose homeostasis. Notably, obese patients with MC4R …