Gout, a chronic inflammatory arthritis disease, is characterized by hyperuricemia and caused
by interactions between genetic, epigenetic, and metabolic factors. Acute gout symptoms are …

Gout arthritis (GA) is a common and curable type of inflammatory arthritis that has been
attributed to a combination of genetic, environmental and metabolic factors. Chronic …

Inflammatory and functional gastrointestinal disorders such as irritable bowel syndrome
(IBS) and obstructive bowel disorder (OBD) underlie the most prevalent forms of visceral …

Background Gout results from disturbed uric acid metabolism, which causes urate crystal
deposition in joints and surrounding tissues. Gout pain management is largely limited to …

Gout is a common type of inflammatory arthritis characterized by the presence of
monosodium urate crystals (MSU) in the joints. Macrophages are believed to be involved in …

Gout is a metabolic disease caused by the deposition of monosodium urate (MSU) crystals
inside joints, which leads to inflammation and tissue damage. Increased concentration of …

Chronic kidney disease (CKD) is a global health concern and public health priority. The
condition often involves inflammation due to the accumulation of toxins and the reduced …

Excessive deposition of monosodium urate (MSU) crystal in the joint results in gout arthritis,
which triggers severe pain and affects life quality. Oxidative stress is a pivotal mechanism …

Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and
inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 …

Gout is a common inflammatory disease. The activation of NLRP3 inflammasome induced
by monosodium urate (MSU) crystals has a critical role in gout, and its prevention is …