A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related
deaths in the world. More than half of patients with HCC present with advanced stage, and …

Introduction Hypoxia is associated with unfavorable prognoses in melanoma patients, and
the limited response rates of patients to PD-1/PD-L1 blockade could be attributed to the …

Radiation therapy is a highly effective method for inhibiting tumor growth and is widely used
in clinical settings. 1 It damages the vital biomolecules (especially DNA) of cancer cells and …

Immunotherapy, including immune checkpoint inhibitors and adoptive cell transfer, has
obtained great progress, but their efficiencies vary among patients due to the genetic and …

Calcium/calmodulin‑dependent protein kinase kinase 2 (CaMKK2) and mitochondrial
sodium/calcium exchanger protein (NCLX) are key regulatory factors in calcium …

Background Mitochondrial alterations, often dependent on unbalanced mitochondrial
dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM) …

Copper plays vital roles in numerous cellular processes and its imbalance can lead to
oxidative stress and dysfunction. Recent research has unveiled a unique form of copper …

The work presents core–shell nanoparticles (NPs) built from the novel Cu (I) complexes with
cyclic P2N2-ligands (1, 5-diaza-3, 7-diphosphacyclooctanes) that can visualize their entry …

Worldwide, tens of thousands of people die from melanoma each year, making it the most
frequently fatal form of cutaneous cancer. Immunotherapeutic advancements, particularly …