Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

The skin microbial community is a multifunctional ecosystem aiding prevention of infections
from transient pathogens, maintenance of host immune homeostasis, and skin health. A …

Psoriasis is the most common autoimmune disease, yet its pathophysiology is not fully
understood. It is now believed that psoriasis is caused by the increased activation of immune …

Therapeutic treatment forms can play significant roles in resolving psoriatic plaques or
promoting wound repair in psoriatic skin. Considering the biocompatibility, mechanical …

Introduction: Cannabidiol (CBD) is the second most abundant Phytocannabinoid in
Cannabis extracts. CBD has a binding affinity for several cannabinoid and cannabinoid …

Expression of immune checkpoint proteins restrict immunosurveillance in the tumor
microenvironment; thus, FDA-approved checkpoint inhibitor drugs, specifically PD-1/PD-L1 …

Background Psoriasis is an immune-mediated chronic inflammatory skin disease
characterized by well-defined erythema and white scales, which affects approximately 2% of …

Selective inhibitors targeting the first bromodomain (BD1) or the second bromodomain
(BD2) of the bromodomain and extra terminal domain (BET) proteins have triggered …

Ethnopharmacological relevance Tripterygium wilfordii polyglycosides (TWP) are extracted
from Tripterygium wilfordii Hook. f., which has the significant effects of anti-inflammation and …