Fibrosis is associated with accumulation of excess fibrillar collagen, leading to tissue
dysfunction. Numerous processes, including inflammation, myofibroblast activation, and …

Background: Diastolic dysfunction (DD) is associated with the development of heart failure
and contributes to the pathogenesis of other cardiac maladies, including atrial fibrillation …

Relaxin is a hormone of pregnancy first discovered for its ability to induce ligament
relaxation in nonpregnant guinea pig and is important for softening of the birth canal during …

Background The peptide hormone relaxin has potent anti-fibrotic and anti-inflammatory
properties in various organs, including the kidneys. However, the protective effects of relaxin …

Obesity and obesity related kidney and liver disease have become more prevalent over the
past few decades, especially in the western world. Sodium-glucose cotransporter 2 (SGLT2) …

Abstract ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult
kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim …

Rationale: Cardiac fibrosis is an integral constituent of every form of chronic heart disease,
and persistence of fibrosis reduces tissue compliance and accelerates the progression to …

The pleiotropic hormone relaxin-2 plays a pivotal role in the physiology and pathology of the
cardiovascular system. Relaxin-2 exerts relevant regulatory functions in cardiovascular …

Fibrosis refers to the scarring and hardening of tissues, which results from a failed immune
system-coordinated wound healing response to chronic organ injury and which manifests …

Hypertension-induced cardiovascular and renal damage can be mediated by activation of
the renin-angiotensin-aldosterone system. There are different factors beyond renin …