Stem cells in the adult brain are specialized astrocytes capable of generating neurons and
glial cells. While neural stem cells (NSCs) and common astrocytes have clearly distinct …

Pancreatic cancer remains one of the deadliest of all cancer types with a 5-year overall
survival rate of just 12%. Preclinical models available for understanding the disease …

Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all cells of the
blood and most immune cells. Due to their capacity for unlimited self-renewal, long-term …

Cutaneous squamous cell carcinoma (cSCC) is a major deleterious health effect of chronic
arsenic (iAs) exposure. The molecular mechanism of arsenic-induced cSCC remains poorly …

Pluripotent stem cells are characterized by their differentiation potential toward endoderm,
mesoderm, and ectoderm. However, it is still largely unclear how these cell-fate decisions …

Primary cell culture is a powerful model system to address fundamental questions about
organismal physiology at the cellular level, especially for species that are difficult, or …

Adult mesenchymal stem cells were reported more than 30 years ago. Since then, their
potential to repair and regenerate damaged or diseased tissues has been studied …

Abstract Background Atypical Teratoid Rhabdoid Tumor (ATRT) is a rare, devastating, and
largely incurable pediatric brain tumor. Although recent studies have uncovered three …

Population aging has increased the global prevalence of aging‐related diseases, including
cancer, sarcopenia, neurological disease, arthritis, and heart disease. Understanding aging …

Cells isolated from their native tissues and cultured in vitro face different selection pressures
than those cultured in vivo. These pressures induce a profound transformation that reshapes …