Being an emerging transdermal delivery tool, nanoemulgel, has proved to show surprising
upshots for the lipophilic drugs over other formulations. This lipophilic nature of majority of …

Poor aqueous solubility is a major challenge in today's biopharmaceutics. While solubility-
enabling formulations can significantly increase the apparent solubility of the drug, the …

For ethical and cost-related reasons, use of animals for the assessment of mode of action,
metabolism and/or toxicity of new drug candidates has been increasingly scrutinized in …

Oral absorption of compounds depends on many physiological, physiochemical and
formulation factors. Two important properties that govern oral absorption are in vitro …

Introduction: Successful oral therapy requires sufficient intestinal absorption to enable the
drug to reach its site of action. Evaluation of intestinal permeability is important for candidate …

A new approach for the synthesis of podophyllotoxin-naphthoquinone compounds using
microwave-assisted three-component reactions is reported in this study. Novel …

Among the great number of poorly soluble drugs in pharmaceutical development, most of
them are weak bases. Typically, they readily dissolve in an acidic environment but are prone …

Active pharmaceutical ingredients (APIs) from the purchase and use of medications are
recognized as ubiquitous contaminants of the environment. Ecological impacts can range …

The purpose of this study was to conduct a head-to-head comparison of different solubility-
enabling formulations, and their consequent solubility–permeability interplay. The low …

The time-resolved uptake of 17 nonionic and ionic polar compounds (log D≤ 2) with a
diversity of functional groups into zebrafish embryos (ZFE) was studied over 96 h of …