[HTML][HTML] Biallelic NAA60 variants with impaired N-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications

V Chelban, H Aksnes, R Maroofian… - Nature …, 2024 - nature.com
Primary familial brain calcification (PFBC) is characterized by calcium deposition in the
brain, causing progressive movement disorders, psychiatric symptoms, and cognitive …

[HTML][HTML] N-terminal processing and modification of ciliary dyneins

M Sakato-Antoku, JL Balsbaugh, SM King - Cells, 2023 - mdpi.com
Axonemal dyneins are highly complex microtubule motors that power ciliary motility. These
multi-subunit enzymes are assembled at dedicated sites within the cytoplasm. At least …

[HTML][HTML] HYPK controls stability and catalytic activity of the N-terminal acetyltransferase A in Arabidopsis thaliana

X Gong, JB Boyer, S Gierlich, M Pożoga… - Cell Reports, 2024 - cell.com
The ribosome-tethered N-terminal acetyltransferase A (NatA) acetylates 52% of soluble
proteins in Arabidopsis thaliana. This co-translational modification of the N terminus …

[HTML][HTML] A Proteogenomic Approach to Unravel New Proteins Encoded in the Leishmania donovani (HU3) Genome

J Adán-Jiménez, A Sánchez-Salvador, E Morato… - Genes, 2024 - mdpi.com
The high-throughput proteomics data generated by increasingly more sensible mass
spectrometers greatly contribute to our better understanding of molecular and cellular …

[HTML][HTML] Bioinformatic Analysis Reveals the Association of Human N-Terminal Acetyltransferase Complexes with Distinct Transcriptional and Post-Transcriptional …

C Koufaris, C Demetriadou, V Nicolaidou… - Biochemical Genetics, 2024 - Springer
N-terminal acetyltransferases (NAT) are the protein complexes that deposit the abundant N-
terminal acetylation (Nt-Ac) on eukaryotic proteins, with seven human complexes currently …

Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish

R Ree, SJ Lin, LO Sti Dahl, K Huang, C Petree… - bioRxiv, 2024 - biorxiv.org
Actin is a key component of the cytoskeleton of eukaryotic cells and is involved in numerous
cellular functions. In animal cells, actins are uniquely N-terminally processed by a dedicated …