Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …

TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Fibrosis refers to the excessive deposition of extracellular matrix components in the
processes of wound repair or tissue regeneration after tissue damage. Fibrosis occurs in …

Laryngeal cancer (LC) is the malignancy of the larynx (voice box). The majority of LC are
squamous cell carcinomas. Many risk factors were reported to be associated with LC as …

Testicular germ cell tumors (TGCTs) are the most common testicular neoplasms in
adolescents and young males. Understanding the genetic basis of TGCTs represents a …

Transcriptional and post-transcriptional regulation shapes the transcriptome and proteome
changes induced by various cellular signaling cascades. MicroRNAs (miRNAs) are small …

Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …

MicroRNAs (miRNAs) as the regulatory short noncoding RNAs are involved in a wide array
of cellular and molecular processes. They negatively regulate gene expression and their …

TGFβ is involved in various biological processes, including development, differentiation,
growth regulation, and epithelial–mesenchymal transition (EMT). In TGFβ/Smad signaling …

In recent years, natural compounds have received considerable attention in preventing and
curing most dreadful diseases including cancer. The reason behind the use of natural …