The emerging role of COX-2, 15-LOX and PPARγ in metabolic diseases and cancer: an introduction to novel multi-target directed ligands (MTDLs)
Emerging evidence supports an intertwining framework for the involvement of different
inflammatory pathways in a common pathological background for a number of disorders. Of …
inflammatory pathways in a common pathological background for a number of disorders. Of …
[HTML][HTML] Analysis of MMP-2-735C/T (rs2285053) and MMP-9-1562C/T (rs3918242) Polymorphisms in the Risk Assessment of Developing Lung Cancer
K Wadowska, P Błasiak, A Rzechonek… - International Journal of …, 2023 - mdpi.com
Matrix metalloproteinase (MMP)-2 and-9 are gelatinases which are capable of degrading
type IV collagen and have been linked to cancer invasion and metastatic development. MMP …
type IV collagen and have been linked to cancer invasion and metastatic development. MMP …
Polymorphisms of COX/PEG2 pathway-related genes are associated with the risk of lung cancer: a case–control study in China
X Liang, J Wang, Y Liu, L Wei, F Tian, J Sun… - International …, 2022 - Elsevier
Abstract Background The COX/PGE2 pathway is widely involved in the development of
tumors and the regulation of tumor immune cells such as T cells, NK cells and DCs …
tumors and the regulation of tumor immune cells such as T cells, NK cells and DCs …
Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region
Abstract Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-
2)] induces the production of prostaglandins as part of the host-immune response to …
2)] induces the production of prostaglandins as part of the host-immune response to …
Associations between folate metabolism enzyme polymorphisms and lung cancer: a meta-analysis
F Chen, T Wen, Q Lv, F Liu - Nutrition and cancer, 2020 - Taylor & Francis
Some previous studies already investigated potential associations between folate
metabolism enzyme polymorphisms and lung cancer (LC). However, the results of these …
metabolism enzyme polymorphisms and lung cancer (LC). However, the results of these …
[HTML][HTML] Influence of variability in the cyclooxygenase pathway on cardiovascular outcomes of nephrosclerosis patients
Nephrosclerosis patients are at an exceptionally high cardiovascular (CV) risk. We aimed to
determine whether genetic variability represented by 38 tag-SNPs in genes of the …
determine whether genetic variability represented by 38 tag-SNPs in genes of the …
Certain interleukin polymorphisms might influence predisposition to lung cancer: A meta‐analysis of 35 published studies
J Gao, Y Ying, J Wang, Y Cui, W Zhang - IUBMB life, 2020 - Wiley Online Library
Interleukin polymorphisms might influence predisposition to lung cancer (LC), but the results
of already published studies regarding the relationship between interleukin polymorphisms …
of already published studies regarding the relationship between interleukin polymorphisms …
[PDF][PDF] COX-2 rs689466 polymorphism correlates with increased lung cancer risk
J Wang, GM Li, XD Wang, FY Zhao, Y Li, JG Sun… - Int J Clin Exp …, 2019 - e-century.us
Background: The aim of this study was to assess, using comprehensive meta-analysis, if
there was a significant association between polymorphisms in cyclooxygenase-2 (COX-2) …
there was a significant association between polymorphisms in cyclooxygenase-2 (COX-2) …
[HTML][HTML] Prostaglandin Synthase 2/Cyclooxygenase 2 Gene Polymorphisms and Susceptibility to Urothelial Bladder Cancer in an Iranian Population
K Mansori, MR Nowroozi, A Farzin… - Middle East Journal …, 2022 - journals.sums.ac.ir
Background: Prostaglandin-endoperoxide synthase 2, recognized as cyclooxygenase 2
(COX-2), is an important enzyme contributing to the generation of proinflammatory …
(COX-2), is an important enzyme contributing to the generation of proinflammatory …
[PDF][PDF] Association between 1195G> A polymorphism of cyclooxygenase-2 gene with lung cancer risk: a meta-analysis
X Wang, T Wei, L Tian, M Wang, Y Qi, Q Shang - Int J Clin Exp Med, 2017 - e-century.us
The studies on the relationship between the 1195G> A polymorphism of cyclooxygenase-2
(COX-2) gene and the risk of lung cancer development have shown conflicting results. A …
(COX-2) gene and the risk of lung cancer development have shown conflicting results. A …