Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …

Legacy per-and polyfluoroalkyl substances (PFASs) have elicited much concern because of
their ubiquitous distribution in the environment and the potential hazards they pose to …

Nuclear receptors are multi-domain transcription factors that bind to DNA elements from
which they regulate gene expression. The peroxisome proliferator-activated receptors …

Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both
transcription factors that perform distinct but overlapping roles in cellular regulation. Here we …

Binding to helix 12 of the ligand-binding domain of PPARγ is required for full agonist activity.
Previously, the degree of stabilization of the activation function 2 (AF-2) surface was thought …

Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high
abundance of membrane lipids is one of myelin's salient features that contribute to its unique …

A promising approach for treating type 2 diabetes mellitus (T2DM) is to target the
Peroxisome Proliferator-Activated Receptor γ (PPARγ) transcription factor, which regulates …

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone
receptor family, attract wide attention as promising therapeutic targets for the treatment of …

The biological impacts of per-and polyfluorinated alkyl substances (PFAS) are linked to their
protein interactions. Existing research has largely focused on serum albumin and liver fatty …

No Heading Biomarkers are increasingly used in drug development to aid scientific and
clinical decisions regarding the progress of candidate and marketed therapeutics …