Precision medicine and cardiac channelopathies: when dreams meet reality
Precision Medicine (PM) is an innovative approach that, by relying on large populations'
datasets, patients' genetics and characteristics, and advanced technologies, aims at …
datasets, patients' genetics and characteristics, and advanced technologies, aims at …
Precision Medicine and Cardiac Channelopathies: Human iPSCs Take the Lead
Sudden cardiac death (SCD) is one of the leading causes of death worldwide, usually
involving young people. SCD remains a critical public health problem accounting for …
involving young people. SCD remains a critical public health problem accounting for …
Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell
Abstract Treatment of cancer has evolved in the last decade with the introduction of new
therapies. Despite these successes, the lingering cardiotoxic side-effects from …
therapies. Despite these successes, the lingering cardiotoxic side-effects from …
An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic proarrhythmia mechanisms
Tuesday, February 22, 2022 303a previously unidentified funny current (If) block by quinine,
which we confirmed with experiments using a HEK-293 expression line and automated …
which we confirmed with experiments using a HEK-293 expression line and automated …
Recent Advances in CRISPR/Cas9 Delivery Approaches for Therapeutic Gene Editing of Stem Cells
M Lotfi, D Morshedi Rad, SS Mashhadi… - Stem cell reviews and …, 2023 - Springer
Rapid advancement in genome editing technologies has provided new promises for treating
neoplasia, cardiovascular, neurodegenerative, and monogenic disorders. Recently, the …
neoplasia, cardiovascular, neurodegenerative, and monogenic disorders. Recently, the …
Deciphering pathogenicity of variants of uncertain significance with CRISPR-edited iPSCs
Genetic variants play an important role in conferring risk for cardiovascular diseases (CVDs).
With the rapid development of next-generation sequencing (NGS), thousands of genetic …
With the rapid development of next-generation sequencing (NGS), thousands of genetic …
Isogenic sets of hiPSC-CMs harboring distinct KCNH2 mutations differ functionally and in susceptibility to drug-induced arrhythmias
KO Brandão, L van den Brink, DC Miller, C Grandela… - Stem cell reports, 2020 - cell.com
Mutations in KCNH2 can lead to long QT syndrome type 2. Variable disease manifestation
observed with this channelopathy is associated with the location and type of mutation within …
observed with this channelopathy is associated with the location and type of mutation within …
Brugada syndrome: different experimental models and the role of human cardiomyocytes from induced pluripotent stem cells
Y Li, S Lang, I Akin, X Zhou… - Journal of the American …, 2022 - Am Heart Assoc
Brugada syndrome (BrS) is an inherited and rare cardiac arrhythmogenic disease
associated with an increased risk of ventricular fibrillation and sudden cardiac death …
associated with an increased risk of ventricular fibrillation and sudden cardiac death …
Dilated cardiomyopathy: a new insight into the rare but common cause of heart failure
P Giri, A Mukhopadhyay, M Gupta, B Mohapatra - Heart Failure Reviews, 2022 - Springer
Heart failure is a global health burden responsible for high morbidity and mortality with a
prevalence of greater than 60 million individuals worldwide. One of the major causes of …
prevalence of greater than 60 million individuals worldwide. One of the major causes of …
Clinical trial in a dish: using patient-derived induced pluripotent stem cells to identify risks of drug-induced cardiotoxicity
Drug-induced cardiotoxicity is a significant clinical issue, with many drugs in the market
being labeled with warnings on cardiovascular adverse effects. Treatments are often …
being labeled with warnings on cardiovascular adverse effects. Treatments are often …