We developed a 96-well plate assay which allows fast, reproducible, and high-throughput
generation of 3D cardiac rings around a deformable optically transparent hydrogel …

Inherited arrhythmias are a heterogeneous group of conditions that confer risk of sudden
death. Many inherited arrhythmias have been linked to pathogenic genetic variants that …

Cerebral cavernous malformations are clusters of aberrant vessels that can lead to severe
neurological complications. Pathogenic loss-of-function variants in the CCM1, CCM2, or …

Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. While both
genetic and environmental factors significantly contribute to the pathogenesis of CVDs …

Background Genetic screening is now commonplace for patients suspected of having
inherited cardiac conditions. Variants of uncertain significance (VUS) in disease-associated …

Long QT syndrome type 2 is a life-threatening disorder of cardiac electrophysiology. It can
lead to sudden cardiac death as a result of QT prolongation and can remain undetected until …

Human induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) offer potential as
an in vitro model for studying drug cardiotoxicity and patient‐specific cardiovascular …

Over the past 2 decades, genome-editing technique has proven to be a robust editing
method that revolutionizes the field of biomedicine. At the genetic level, it can be efficiently …

Inherited arrhythmic disorders are a group of heterogeneous diseases predisposing to life-
threatening arrhythmias and sudden cardiac death. Their diagnosis is not always simple due …

Personalized regenerative medicine and biomedical research have been galvanized and
revolutionized by human pluripotent stem cells in combination with recent advances in …