Background Long-QT syndrome type 2 (LQT2) is a common malignant hereditary
arrhythmia. Due to the lack of suitable animal and human models, the pathogenesis of LQT2 …

Congenital heart disease (CHD) represents a significant risk factor with profound
implications for neonatal survival rates and the overall well-being of adult patients. The …

Aims To establish a KCNQ1 mutant-specific induced pluripotent stem cell (iPSC) model of a
Chinese inherited long QT syndrome (LQTS) patient and to explore the pathogenesis of …

The human Ether-à-go-go Related Gene (hERG) encodes the pore forming subunit of the
channel that conducts the rapid delayed rectifier potassium current I Kr. I Kr drives …

Introduction: Inherited arrhythmias are an uncommon, but malignant family of cardiac
diseases that result from genetic abnormalities in the ion channels and/or structural proteins …

Recent advances in human induced pluripotent stem cell (iPSC) technology may provide
unprecedented opportunities to study patient‐specific responses to anaesthetics and …

Congenital long QT syndrome type 2 (LQT2) results from KCNH2 mutations that cause loss
of Kv11. 1 channel function which can lead to arrhythmias, syncope, and sudden death …

From carrying potentially pathogenic genes to severe clinical phenotypes, the basic
research in the inherited cardiac ion channel disease such as long QT syndrome (LQTS) …

Type 2 long QT syndrome (LQT2) is the second most common subtype of long QT syndrome
and is caused by mutations in KCHN2 encoding the rapidly activating delayed rectifier …

Radiology and Director of Stanford Cardiovascular Institute, was drawn to cardiology
because he was fascinated by the beating heart—“the center of melodic, rhythmic motion …