Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Injectable double‐crosslinked adhesive hydrogels with high mechanical resilience and effective energy dissipation for joint wound treatment

K Chen, Z Wu, Y Liu, Y Yuan… - Advanced Functional …, 2022 - Wiley Online Library
Due to the moist environment and inevitable movement, efficient wound closure and healing
of vulnerable joint skin remains a great challenge. Herein, a poly (γ‐glutamic acid) …

[HTML][HTML] Skin barrier abnormalities and immune dysfunction in atopic dermatitis

G Yang, JK Seok, HC Kang, YY Cho, HS Lee… - International journal of …, 2020 - mdpi.com
Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin
barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to …

Trial of nemolizumab and topical agents for atopic dermatitis with pruritus

K Kabashima, T Matsumura, H Komazaki… - … England Journal of …, 2020 - Mass Medical Soc
Background Nemolizumab is a subcutaneously administered humanized monoclonal
antibody against interleukin-31 receptor A, which is involved in pruritus and inflammation in …

Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Ångstrom-scale silver particle–embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation

CY Chen, H Yin, X Chen, TH Chen, HM Liu, SS Rao… - Science …, 2020 - science.org
Poor wound healing after diabetes or extensive burn remains a challenging problem.
Recently, we presented a physical approach to fabricate ultrasmall silver particles from …

[HTML][HTML] Microbiome and human aging: probiotic and prebiotic potentials in longevity, skin health and cellular senescence

JL Boyajian, M Ghebretatios, S Schaly, P Islam… - Nutrients, 2021 - mdpi.com
The role of the microbiome in human aging is important: the microbiome directly impacts
aging through the gastrointestinal system. However, the microbial impact on skin has yet to …

[HTML][HTML] Gut–skin axis: unravelling the connection between the gut microbiome and psoriasis

AYK Thye, YR Bah, JWF Law, LTH Tan, YW He… - Biomedicines, 2022 - mdpi.com
Evidence has shown that gut microbiome plays a role in modulating the development of
diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The …

[HTML][HTML] Delgocitinib ointment, a topical Janus kinase inhibitor, in adult patients with moderate to severe atopic dermatitis: A phase 3, randomized, double-blind …

H Nakagawa, O Nemoto, A Igarashi, H Saeki… - Journal of the American …, 2020 - Elsevier
Background Previous studies showed the potential effectiveness of delgocitinib ointment, a
novel topical Janus kinase inhibitor, in atopic dermatitis (AD). Objective This study aimed to …