The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications
JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing global pandemic has presented a health emergency of unprecedented …
and the ensuing global pandemic has presented a health emergency of unprecedented …
[HTML][HTML] Coagulopathy in COVID‐19
The COVID‐19 pandemic has become an urgent issue in every country. Based on recent
reports, the most severely ill patients present with coagulopathy, and disseminated …
reports, the most severely ill patients present with coagulopathy, and disseminated …
Tissue factor: an essential mediator of hemostasis and trigger of thrombosis
SP Grover, N Mackman - Arteriosclerosis, thrombosis, and …, 2018 - Am Heart Assoc
Tissue factor (TF) is the high-affinity receptor and cofactor for factor (F) VII/VIIa. The TF-FVIIa
complex is the primary initiator of blood coagulation and plays an essential role in …
complex is the primary initiator of blood coagulation and plays an essential role in …
Melatonin potentials against viral infections including COVID-19: Current evidence and new findings
Viral infections are dangerous diseases for human health worldwide, which lead to
significant morbidity and mortality each year. Because of their importance and the lack of …
significant morbidity and mortality each year. Because of their importance and the lack of …
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
Without an approved vaccine or treatments, Ebola outbreak management has been limited
to palliative care and barrier methods to prevent transmission. These approaches, however …
to palliative care and barrier methods to prevent transmission. These approaches, however …
The pathogenesis of Ebola virus disease
L Baseler, DS Chertow, KM Johnson… - Annual Review of …, 2017 - annualreviews.org
For almost 50 years, ebolaviruses and related filoviruses have been repeatedly reemerging
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …
across the vast equatorial belt of the African continent to cause epidemics of highly fatal …
Platelets and infection–an emerging role of platelets in viral infection
A Assinger - Frontiers in immunology, 2014 - frontiersin.org
Platelets are anucleate blood cells that play a crucial role in the maintenance of hemostasis.
While platelet activation and elevated platelet counts (thrombocytosis) are associated with …
While platelet activation and elevated platelet counts (thrombocytosis) are associated with …
[HTML][HTML] Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
L Oestereich, A Lüdtke, S Wurr, T Rieger… - Antiviral research, 2014 - Elsevier
Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case
fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is …
fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is …
Ebola haemorrhagic fever
H Feldmann, TW Geisbert - The Lancet, 2011 - thelancet.com
Ebola viruses are the causative agents of a severe form of viral haemorrhagic fever in man,
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
designated Ebola haemorrhagic fever, and are endemic in regions of central Africa. The …
Host-directed therapies for infectious diseases: current status, recent progress, and future prospects
Despite extensive global efforts in the fight against killer infectious diseases, they still cause
one in four deaths worldwide and are important causes of long-term functional disability …
one in four deaths worldwide and are important causes of long-term functional disability …