T follicular helper (Tfh) cells provide essential help to B cells for effective antibody-mediated
immune responses. Although the crucial function of these CD4+ T cells in infection and …

Rheumatoid arthritis is a prototypical autoimmune disease that causes joint inflammation
and destruction. There is currently no cure for rheumatoid arthritis, and the effectiveness of …

The interactions between T cells and B cells are essential for antibody responses and the
development of autoimmune diseases. Recently, a distinct subset of T cells capable of …

OBJECTIVE Previous studies showed that inhibiting lymphocyte costimulation reduces
declining β-cell function in individuals newly diagnosed with type 1 diabetes. We tested …

Castleman disease (CD) is a rare lymphoproliferative disorder. Among subtypes of CD,
idiopathic multicentric CD-not otherwise specified (iMCD-NOS) has a poor prognosis and its …

Objectives To investigate the immune cell profiles of patients with systemic lupus
erythematosus (SLE), and to identify longitudinal changes in those profiles over time …

B cells and T cells collaborate in multiple sclerosis (MS) pathogenesis. IgH [MOG] mice
possess a B cell repertoire skewed to recognize myelin oligodendrocyte glycoprotein …

Fine-mapping and functional studies implicate rs117701653, a non-coding single nucleotide
polymorphism in the CD28/CTLA4/ICOS locus, as a risk variant for rheumatoid arthritis and …

Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …

Immune checkpoint receptors are key players in regulating the immune response. They are
responsible for both generating an immune response sufficient to kill invading pathogens …