Biomedical application of chitosan-based nanoscale delivery systems: Potential usefulness in siRNA delivery for cancer therapy
Gene therapy is an emerging and promising strategy in cancer therapy where small
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …
interfering RNA (siRNA) system has been deployed for down-regulation of targeted gene …
CXCR4 regulates growth of both primary and metastatic breast cancer
The chemokine receptor CXCR4 and its cognate ligand CXCL12 recently have been
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
proposed to regulate the directional trafficking and invasion of breast cancer cells to sites of …
Organ selectivity in metastasis: regulation by chemokines and their receptors
A Ben-Baruch - Clinical & experimental metastasis, 2008 - Springer
Cancer metastasis results from a non-random process, in which organ selectivity by the
tumor cells is largely determined by factors that are expressed at the remote organs that …
tumor cells is largely determined by factors that are expressed at the remote organs that …
Circadian regulation of molecular, dietary, and metabolic signaling mechanisms of human breast cancer growth by the nocturnal melatonin signal and the …
DE Blask, SM Hill, RT Dauchy, S Xiang… - Journal of pineal …, 2011 - Wiley Online Library
This review article discusses recent work on the melatonin‐mediated circadian regulation
and integration of molecular, dietary, and metabolic signaling mechanisms involved in …
and integration of molecular, dietary, and metabolic signaling mechanisms involved in …
The multifaceted roles of chemokines in malignancy
A Ben-Baruch - Cancer and metastasis reviews, 2006 - Springer
Tumor development and progression are multifactorial processes, regulated by a large
variety of intrinsic and microenvironmental factors. A key role in cancer is played by …
variety of intrinsic and microenvironmental factors. A key role in cancer is played by …
Molecular mechanisms of melatonin anticancer effects
SM Hill, T Frasch, S Xiang, L Yuan… - Integrative cancer …, 2009 - journals.sagepub.com
The authors have shown that, via activation of its MT1 receptor, melatonin modulates the
transcriptional activity of various nuclear receptors and the proliferation of both ERα+ and …
transcriptional activity of various nuclear receptors and the proliferation of both ERα+ and …
The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study
O Salvucci, A Bouchard, A Baccarelli… - Breast cancer research …, 2006 - Springer
The chemokine receptor CXCR4 is an important factor in the migration, invasiveness,
metastasis and proliferation of breast cancer cells. We have retrospectively analyzed the …
metastasis and proliferation of breast cancer cells. We have retrospectively analyzed the …
A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer
EH Huang, B Singh, M Cristofanilli, J Gelovani… - Journal of Surgical …, 2009 - Elsevier
BACKGROUND: CXCL12/CXCR4 signaling may be involved in tumor growth and
angiogenesis, and homing of cancer cells to bone and other organs. Our purpose was to …
angiogenesis, and homing of cancer cells to bone and other organs. Our purpose was to …
SLITs Suppress Tumor Growth In vivo by Silencing Sdf1/Cxcr4 within Breast Epithelium
R Marlow, P Strickland, JS Lee, X Wu, M PeBenito… - Cancer research, 2008 - AACR
The genes encoding Slits and their Robo receptors are silenced in many types of cancer,
including breast, suggesting a role for this signaling pathway in suppressing tumorigenesis …
including breast, suggesting a role for this signaling pathway in suppressing tumorigenesis …