Immune checkpoint inhibition and chimeric antigen receptor (CAR) T cell therapy have
demonstrated stunning clinical efficacy in many cancer types. However, most patients do not …

It has been 10 years since the role of a chemokine receptor, CXCR4, in breast cancer
metastasis was first documented. Since then, the field of chemokines and cancer has grown …

Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved
in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer …

Chemokines (chemo‐attractant cytokines) are a group of small proteins that act together with
their cell surface receptors, in development, normal physiology and immune responses, to …

Late-stage breast cancer metastasis is driven by dysregulated TGF-β signaling, but the
underlying molecular mechanisms have not been fully elucidated. We attempted to …

Metformin (Met) is an approved antidiabetic drug currently being explored for repurposing in
cancer treatment based on recent evidence of its apparent chemopreventive properties. Met …

Cancer-specific alterations in DNA methylation are hallmarks of human malignancies;
however, the nature of the breast cancer epigenome and its effects on metastatic behavior …

Cancer cells are long known to exhibit increased aerobic glycolysis, but glycolytic inhibition
has not offered a viable chemotherapeutic strategy in part because of the systemic toxicity of …

Chemokines and chemokine receptors are extensively and broadly involved in cancer
metastasis. Previously, we demonstrated that epigenetic silencing of the chemokine …

Reduced epithelial cadherin (E-cad) is a hallmark of invasive carcinomas that have acquired
epithelial-mesenchymal transition (EMT) phenotypes. Here we show that down-regulated E …