The blood–brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial
cells, but its normal function also depends on paracrine interactions between the brain …

Optimal cardiac function depends on proper timing of excitation and contraction in various
regions of the heart, as well as on appropriate heart rate. This is accomplished via …

About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

Abstract 2852 The polyphenolic phytoalexin resveratrol (RSV) and its analogues have
received tremendous attention over the past couple of decades because of a number of …

The sulfonylurea receptor 1 (Sur1)-regulated NCCa-ATP channel is a nonselective cation
channel that is regulated by intracellular calcium and adenosine triphosphate. The channel …

Sulfonylurea compounds were the first available oral antidiabetic agents and they remain an
important tool in our quest for optimal glucose control. The sulfonylureas stimulate the …

Sulphonylureas have been commercially available since the 1950s, but their use continues
to be associated with controversy. Although adverse cardiovascular outcomes in some …

The movement of ions across specific channels embedded on the membrane of individual
cardiomyocytes is crucial for the generation and propagation of the cardiac electric impulse …

Multidrug ABC transporters such as P-glycoprotein (P-gp/MDR1/ABCB1) and multidrug
resistance protein 1 (MRP1/ABCC1) play an important role in the extrusion of drugs from the …

Sulfonylurea receptor 1 (SUR1) is a member of the adenosine triphosphate (ATP)-binding
cassette (ABC) protein superfamily, encoded by Abcc8, and is recognized as a key mediator …