Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Monoamines are involved in regulating the endogenous pain system and indeed, peripheral
and central monoaminergic dysfunction has been demonstrated in certain types of pain …

Monosodium glutamate (MSG) is a neuroexcitatory amino acid commonly used as flavoring
of foods. MSG neonatal administration to animals leads to behavioral and physiological …

Introduction: Mediators in pain transmission are the targets of a multitude of different
analgesic pharmaceuticals. This review explores the most significant mediators of pain …

We investigated the effects of histamine and GABA A receptor agents on pain and
depression-like behaviors and their interaction using a tail-flick test and the forced swimming …

Hydrogen sulfide (H 2 S) is a gasotransmitter synthesized in peripheral tissues by the
enzyme cystathionine gamma-lyase (CSE). This gas has been documented to be involved in …

Among the histamine receptors, growing evidence points to the histamine H3 receptor as a
pharmacological candidate to counteract the autonomic neuropathy associated with …

Among brain structures receiving efferent projections from the histaminergic
tuberomammillary nucleus is the pontine locus coeruleus (LC) involved in descending …

Many areas of the brain along with neurotransmitters involve in processing of nociceptive,
emotional and cognitive dimensions of neuropathic pain. Brian neuronal histamine through …

Background The present study was aimed to investigate the effects of microinjection of
histamine and its H 1, H 2 and H 3 receptor antagonists, mepyramine, ranitidine and …