The pharmacokinetics profile of active pharmaceutical ingredients (APIs) in the solid
pharmaceutical dosage forms is largely dependent on the solid-state characteristics of the …

Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …

The most favored approach for drug administration is the oral route. Several anticancer
drugs come under this category and mostly lack solubility and oral bioavailability, which are …

The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires
numerous processes during which there is risk of dissociation into parent molecules …

Pharmaceutical cocrystals, owing to their manifold applications, are acting as bridge
between drug discovery and pharmaceutical product development. The ability to scale up …

Highlights•Solvent solution crystallization allows best control of material attributes of co-
crystals.•Crystal structures of co-crystals directly govern mechanical properties.•Tabletability …

The disadvantages of active ingredients extracted from medicinal plants due to poor
solubility in the body and low bioavailability limit their clinical application. Pharmaceutical …

Recently, the co-crystallization of pharmaceutical drugs is gaining consideration because it
is an environmentally friendly and potentially effective technique to improve the solubility …

Formation of co-crystals using spray drying remains a challenging task due to the rapid
nature of the process and the possible impact of solvents on the formation of the co-crystals …

The expansion of a novel product is constrained by an active medicinal ingredient's poor
solubility in aqueous solutions and limited oral bioavailability. A novel strategy to improve …