Apoptosis or programmed cell death may play a critical role in AIDS pathogenesis through
depletion of both CD4+ and CD8+ T lymphocytes. Using a reporter virus, a recombinant HIV …

ABSTRACT HIV persists, despite immune responses and antiretroviral therapy, in viral
reservoirs that seed rebound viremia if therapy is interrupted. Previously, we showed that the …

Numerous studies published in the past two decades have identified the viral protein R (Vpr)
as one of the most versatile proteins in the life cycle of human immunodeficiency virus type 1 …

To identify the domains of Vpr that are involved nuclear localization, we transfected HeLa
cells with a panel of expression vectors that encode mutant Vpr protein with deletions or …

Viruses have evolved numerous mechanisms to evade the host immune system and one of
the strategies developed by HIV is to activate apoptotic programs that destroy immune …

It is now well admitted that HIV infection leading to AIDS is associated with an abnormal
susceptibility of T cells to undergo apoptosis. Recent progress in research into programmed …

Induction of apoptosis of virus-infected cells is an important host cell defence mechanism.
However, some viruses have incorporated genes that encode anti-apoptotic proteins or …

Abstract Background Hepatitis C Virus (HCV) infection is associated with chronically
evolving disease and development of hepatocellular carcinoma (HCC), albeit the …

HIV infection and the progression to AIDS are characterized by the depletion of CD4+ T cells
through apoptosis of the uninfected bystander cells and the direct killing of HIV-infected …

We investigated the effect of vpr, physiologically expressed during the course of an acute
HIV-1 infection, on the response of infected cells to apoptotic stimuli as well as on the HIV …