Some viral infections are reported to influence the susceptibility of peripheral blood
mononuclear cells (PBMC) to apoptosis, which is related to disease progression. The …

Mononuclear phagocytic cells and CD4+ T lymphocytes represent the major targets for
infection by HIV-1 in vivo. The most severe pathogenic features associated with HIV-1 …

We recently suggested that, in muscular dystrophies, the excessive accumulation of
adenosine as a result of an altered purine metabolism may contribute to progressive …

抄録 We demonstrate that glycyrrhizin (GL) enhanced Fas-mediated apoptotic body
formation and DNA fragmentation in T cell lines although GL alone did not induce apoptosis …

Programmed Death-1 (PD-1), a member of T cell costimulatory molecules is expressed in
high levels on antigen specific T cells during chronic viral infection, whereas PD-1 …

The depletion of CD4+ T-lymphocytes central to the immunodeficiency in acquired
immunodeficiency syndrome (AIDS) is largely mediated by apoptosis of both infected and …

Vpr, one of the accessory gene products of HIV-1, is a 96-residue protein with several
functions. It is involved in import of the HIV-1 preintegration complex into the nucleus of …

We have previously shown that CD4+ T Jurkat cells constitutively expressing low levels of
the human immunodeficiency virus 1 (HIV-1) vpr protein were less susceptible to undergo …

While a main feature of HIV-1 pathogenesis is the death of CD4+ T cells due to apoptosis,
the mechanisms of apoptosis are highly controversial (1, 2). Several HIV-1 proteins have …

RNA viruses are well known for the enormous genetic variation. Retroviruses share this
feature with other RNA viruses, and human immunodeficiency virus type 1 (HIV-1) has been …