Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

One of the most relevant dose-limiting adverse effects of platinum drugs is the development
of a sensory peripheral neuropathy that highly impairs the patients' quality of life. Nowadays …

Chemotherapy-induced pain is a dose-limiting condition that affects 30% of patients
undergoing chemotherapy. We found that gut microbiota promotes the development of …

Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a
long-lasting reduction in K+ channel expression in the dorsal root ganglion (DRG), but little …

Anti-neoplastic agents in the platinum-complex, taxane, vinca alkaloid, and proteasome-
inhibitor classes induce a dose-limiting, chronic, distal, symmetrical, sensory peripheral …

Oxaliplatin is an integral component of colorectal cancer therapy, but its clinical use is
associated with a dose-limiting peripheral neurotoxicity. We found that the organic cation …

Cold allodynia, pain in response to cooling, occurs during or within hours of oxaliplatin
infusion and is thought to arise from a direct effect of oxaliplatin on peripheral sensory …

Summary Nav1. 7, a peripheral neuron voltage-gated sodium channel, is essential for pain
and olfaction in mice and humans. We examined the role of Nav1. 7 as well as Nav1. 3 …

Oxaliplatin, a platinum-based chemotherapeutic agent, has become a standard treatment for
advanced colorectal cancer. The dose-limiting toxicity of this compound is the development …

Neurotoxicity remains the most common adverse effect of oxaliplatin, limiting its clinical use.
In the present study, we developed a mouse model of chronic oxaliplatin-induced …