Proteomic fingerprint of lung fibrosis progression and response to therapy in bleomycin-induced mouse model

L Principi, E Ferrini, R Ciccimarra, L Pagani… - International journal of …, 2023 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by the aberrant
accumulation of extracellular matrix in the lungs. nintedanib is one of the two FDA-approved …

A fully automated micro‑CT deep learning approach for precision preclinical investigation of lung fibrosis progression and response to therapy

M Buccardi, E Ferrini, F Pennati, E Vincenzi… - Respiratory …, 2023 - Springer
Micro-computed tomography (µCT)-based imaging plays a key role in monitoring disease
progression and response to candidate drugs in various animal models of human disease …

A fully automated deep learning pipeline for micro-CT-imaging-based densitometry of lung fibrosis murine models

E Vincenzi, A Fantazzini, C Basso, A Barla… - Respiratory …, 2022 - Springer
Idiopathic pulmonary fibrosis, the archetype of pulmonary fibrosis (PF), is a chronic lung
disease of a poor prognosis, characterized by progressively worsening of lung function …

Micro-CT-assisted identification of the optimal time-window for antifibrotic treatment in a bleomycin mouse model of long-lasting pulmonary fibrosis

M Buccardi, A Grandi, E Ferrini, D Buseghin… - Scientific Reports, 2024 - nature.com
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a debilitating and fatal lung disease
characterized by the excessive formation of scar tissue and decline of lung function. Despite …

Single, Double and Triple-hit Strategies to Establish a Long-term Premature Rabbit Model of Bronchopulmonary Dysplasia

C Catozzi, F Stretti, E Scalera, M Storti, A Modena… - 2024 - researchsquare.com
Background Bronchopulmonary dysplasia (BPD) is a chronic lung condition of premature
neonates, yet without an established pharmacological treatment. The BPD rabbit model …