Genetic and Epigenetic Mechanisms of Psoriasis

L Mateu-Arrom, L Puig - Genes, 2023 - mdpi.com
Psoriasis is a disease involving the innate and adaptative components of the immune
system, and it is triggered by environmental factors in genetically susceptible individuals …

Tissue tregs and maintenance of tissue homeostasis

Q Shao, J Gu, J Zhou, Q Wang, X Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Regulatory T cells (Tregs) specifically expressing Forkhead box P3 (Foxp3) play roles in
suppressing the immune response and maintaining immune homeostasis. After maturation …

Orchestrated cytokines mediated by biologics in psoriasis and its mechanisms of action

AA Mohd Noor, M Azlan, N Mohd Redzwan - Biomedicines, 2022 - mdpi.com
Psoriasis is an autoimmune disease mediated by disturbed T cells and other immune cells,
and is defined by deep-red, well-demarcated skin lesions. Due to its varied etiologies and …

Therapeutic potential of adipose tissue‐derivatives in modern dermatology

B Bellei, E Migliano, M Picardo - Experimental Dermatology, 2022 - Wiley Online Library
Stem cell‐mediated therapies in combination with biomaterial and growth factor‐based
approaches in regenerative medicine are rapidly evolving with increasing application …

Inhibition of interleukin-2-inducible T-cell kinase causes reduction in imiquimod-induced psoriasiform inflammation through reduction of Th17 cells and enhancement …

A Nadeem, SF Ahmad, NO Al-Harbi, KE Ibrahim… - Biochimie, 2020 - Elsevier
Psoriasis is a debilitating chronic skin disease with a worldwide prevalence. Its main
features include well-marked silvery scales on the skin of hands and feet and back which …

The imbalance of Th17/Treg via STAT3 activation modulates cognitive impairment in P. gingivalis LPS-induced periodontitis mice

X Zhang, X Zhang, C Qiu, H Shen… - Journal of leukocyte …, 2021 - academic.oup.com
Periodontitis is one of the most common oral diseases worldwide, and it is associated with
various systemic diseases, including cognitive diseases. STAT3 regulates the inflammatory …

Th17-related cytokines as potential discriminatory markers between neuromyelitis optica (Devic's disease) and multiple sclerosis—A review

K Maciak, S Pietrasik, A Dziedzic, J Redlicka… - International Journal of …, 2021 - mdpi.com
Multiple sclerosis (MS) and Devic's disease (NMO; neuromyelitis optica) are autoimmune,
inflammatory diseases of the central nervous system (CNS), the etiology of which remains …

MicroRNA-125a-5p regulates the effect of Tregs on Th1 and Th17 through targeting ETS-1/STAT3 in psoriasis

K Yan, F Zhang, J Ren, Q Huang, N Yawalkar… - Journal of translational …, 2023 - Springer
Background Psoriasis is an inflammatory disease mediated by helper T (Th) 17 and Th1
cells. MicroRNA-125a (miR-125a) is reduced in the lesional skin of psoriatic patients …

[HTML][HTML] IL-17 and IL-21: their immunobiology and therapeutic potentials

CH Koh, BS Kim, CY Kang, Y Chung, H Seo - Immune Network, 2024 - ncbi.nlm.nih.gov
Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in the
modulation of a wide range of immune responses. IL-17 serves as a critical defender against …

[HTML][HTML] Regulatory T cells and inflammatory mediators in autoimmune disease

V Gouirand, I Habrylo, MD Rosenblum - Journal of Investigative …, 2022 - Elsevier
Regulatory T cells (Tregs) play a critical role in regulating tissue inflammation. Reduced
Treg numbers and/or suppressive function contribute to autoimmune disease. Tregs can …