Background Elevated IL‐21 expression which can effectively induce Th17 cell differentiation
has been implicated in the pathogenesis of psoriasis, but its role in angiogenesis remains …

Recent studies have indicated a key role of the impaired suppressive capacity of regulatory
T cells (Tregs) in psoriasis (PsO) pathogenesis. However, the genetic background of Treg …

Background Mood disorders have been associated with risk of clinical relapses in multiple
sclerosis (MS), a demyelinating disease mediated by myelin-specific T cells. Objectives We …

Background Regulatory T (Treg) cells, which prevent inflammation-induced eosinophil
infiltration, are deficient in nasal polyps (NPs) in patients with eosinophilic chronic …

Germline gain-of-function (GOF) variants in STAT3 cause an inborn error of immunity
associated with early-onset poly-autoimmunity and immune dysregulation. To study tissue …

Background: Cannabinoid receptor 2 (CB2R) is a potential target for anti-inflammatory and
pain therapeutics given its significant immunomodulatory and analgesic effects. However …

Background Psoriasis is a T cell–mediated autoimmune skin disease. Accumulating
evidence has demonstrated that co-inhibitory receptors (CIRs) play a vital role in regulating …

Diosmin is a flavonoid with promising anti-inflammatory and antioxidant properties.
However, it has difficult physicochemical characteristics since its solubility demands a pH …

Immune thrombocytopenia is a common heterogeneous autoimmune disease that is
characterized by decreasing peripheral blood platelet counts and increasing risk of …

Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated
inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized …