Qingre lishi decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated …
X Zhu, Q Xu, Z Liu, Z Cao, M Li, J Wei, L Du… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Psoriasis, an immune system disorder, is a chronic
relapsing disease that cannot be cured. Chinese herbal medicine is gradually considered a …
relapsing disease that cannot be cured. Chinese herbal medicine is gradually considered a …
A sharp decrease of Th17, CXCR3+-Th17, and Th17.1 in peripheral blood is associated with an early anti-IL-17-mediated clinical remission in psoriasis
Psoriasis—an immune-mediated skin disease—implicates in its pathophysiology by
circulating pro-inflammatory cell populations, cytokines, and their interactions with the …
circulating pro-inflammatory cell populations, cytokines, and their interactions with the …
High‐dimensional analysis defines multicytokine T‐cell subsets and supports a role for IL‐21 in atopic dermatitis
T Czarnowicki, HJ Kim, AP Villani, J Glickman… - Allergy, 2021 - Wiley Online Library
Background Flow cytometry is a well‐accepted approach for immune profiling; however, its
value is restricted by the limited number of markers that can be analyzed simultaneously …
value is restricted by the limited number of markers that can be analyzed simultaneously …
Targeting Myeloid‐Derived Suppressor Cells Is a Novel Strategy for Anti‐Psoriasis Therapy
Psoriasis is a common immune‐mediated, chronic inflammatory genetic‐related disease
that affects patients' quality of life. Myeloid‐derived suppressor cells (MDSCs) are a …
that affects patients' quality of life. Myeloid‐derived suppressor cells (MDSCs) are a …
[HTML][HTML] Interleukin-21 modulates balance between regulatory T cells and T-helper 17 cells in chronic hepatitis B virus infection
Y Cai, H Ji, X Zhou, K Zhao, X Zhang, L Pan… - BMC Infectious …, 2023 - Springer
Background Chronic HBV infection is always accompanied by differences in the balance
between regulatory T cells (Tregs) and T-helper 17 (Th17) cells in infection phases. IL-21 …
between regulatory T cells (Tregs) and T-helper 17 (Th17) cells in infection phases. IL-21 …
[HTML][HTML] Remodeling of T-cell mitochondrial metabolism to treat autoimmune diseases
T cells are key drivers of the pathogenesis of autoimmune diseases by producing cytokines,
stimulating the generation of autoantibodies, and mediating tissue and cell damage. Distinct …
stimulating the generation of autoantibodies, and mediating tissue and cell damage. Distinct …
The possible pathogenic role of IgG4-producing plasmablasts in stricturing Crohn's disease
Background: Crohn's disease (CD) is a condition on the spectrum of inflammatory bowel
disease that affects up to 20 people per 100,000 in the US annually, and with incidence …
disease that affects up to 20 people per 100,000 in the US annually, and with incidence …
[HTML][HTML] IL-6 Is Not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium tuberculosis H37rv
K Ritter, JC Sodenkamp, A Hölscher, J Behrends… - Cells, 2020 - mdpi.com
Anti-inflammatory treatment of chronic inflammatory diseases often increases susceptibility
to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and …
to infectious diseases such as tuberculosis (TB). Since numerous chronic inflammatory and …
[HTML][HTML] Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis
X Liu, L Chen, W Peng, H Deng, H Ni, H Tong… - Frontiers in …, 2024 - frontiersin.org
Sepsis is a multi-organ dysfunction characterized by an unregulated host response to
infection. It is associated with high morbidity, rapid disease progression, and high mortality …
infection. It is associated with high morbidity, rapid disease progression, and high mortality …