The late endosomes/endo‐lysosomes of vertebrates contain an atypical phospholipid,
lysobisphosphatidic acid (LBPA)(also termed bis [monoacylglycero] phosphate [BMP]) …

The concept of central nervous system (CNS) inflammation has evolved over the last
decades. Neuroinflammation is the response of reactive CNS components to altered …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by
mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although …

Cyclodextrins, representing a versatile family of cyclic oligosaccharides, have extensive
pharmaceutical applications due to their unique truncated cone-shaped structure with a …

This review discusses how lipophagy and cytosolic lipolysis degrade cellular lipids, as well
as how these pathway ys communicate, how they affect lipid metabolism and energy …

Abstract Background Niemann-Pick Disease Type C1 (NPC1) is a disorder of intracellular
cholesterol and lipid trafficking that leads to the accumulation of cholesterol and lipids in the …

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus (SARS-CoV)-2 has resulted in the death of more than 328,000 …

Chondroitin sulfate proteoglycans (CSPGs), extracellular matrix molecules that increase
dramatically following a variety of CNS injuries or diseases, have long been known for their …

Abstract Background Niemann-Pick Disease Type C (NPC) is an autosomal recessive rare
disease characterised by progressive neurovisceral manifestations. The collection of on …