Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …

Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …

Hepatic stellate cells (HSCs) activation play a significant role in the progression of hepatic
fibrosis. During chronic liver diseases, hepatocytes are damaged severely and secrete …

Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …

Opinion statement Hepatocellular carcinoma is the fourth leading cause of cancer-related
deaths worldwide and its associated mortality rate is expected to rise within the next decade …

Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation
process consisting in altered deposition of extracellular matrix. Progression of fibrosis can …

Background Liver diseases have a negative impact on global health and are a leading
cause of death worldwide. Chlorogenic acids (CGAs), a family of esters formed between …

Liver fibrosis is a chronic pathological process that various pathogenic factors lead to
abnormal hyperplasia of hepatic connective tissue, and its main feature is the excessive …

ABSTRACT Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in
Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic …