RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
K Newton, DL Dugger, A Maltzman, JM Greve… - Cell Death & …, 2016 - nature.com
Necroptosis is a caspase-independent form of cell death that is triggered by activation of the
receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its …
receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its …
Necroptosis and its role in inflammation
M Pasparakis, P Vandenabeele - Nature, 2015 - nature.com
Regulated cell death has essential functions in development and in adult tissue
homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires …
homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires …
The diverse role of RIP kinases in necroptosis and inflammation
Inflammation is a healthy response to infection or danger and should be rapid, specific and
terminated once the threat has passed. Inflammatory diseases, where this regulation fails …
terminated once the threat has passed. Inflammatory diseases, where this regulation fails …
SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
Y Yue, NR Nabar, CS Shi, O Kamenyeva, X Xiao… - Cell death & …, 2018 - nature.com
The molecular mechanisms underlying the severe lung pathology that occurs during SARS-
CoV infections remain incompletely understood. The largest of the SARS-CoV accessory …
CoV infections remain incompletely understood. The largest of the SARS-CoV accessory …
Inflammation and its resolution as determinants of acute coronary syndromes
Inflammation contributes to many of the characteristics of plaques implicated in the
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …
pathogenesis of acute coronary syndromes. Moreover, inflammatory pathways not only …
[HTML][HTML] Necroptosis in health and diseases
W Zhou, J Yuan - Seminars in cell & developmental biology, 2014 - Elsevier
Necroptosis is a form of regulated necrosis that can be activated by ligands of death
receptors and stimuli that induce the expression of death receptor ligands under apoptotic …
receptors and stimuli that induce the expression of death receptor ligands under apoptotic …
Necroptosis and inflammation
K Newton, G Manning - Annual review of biochemistry, 2016 - annualreviews.org
Necroptosis is a regulated form of necrosis, with the dying cell rupturing and releasing
intracellular components that can trigger an innate immune response. Toll-like receptor 3 …
intracellular components that can trigger an innate immune response. Toll-like receptor 3 …
Flipping the dogma–phosphatidylserine in non-apoptotic cell death
The exposure of phosphatidylserine (PS) on the outer plasma membrane has long been
considered a unique feature of apoptotic cells. Together with other “eat me” signals, it …
considered a unique feature of apoptotic cells. Together with other “eat me” signals, it …
Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis
Elevated hematocrit is associated with cardiovascular risk; however, the causality and
mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk …
mechanisms are unclear. The JAK2V617F (Jak2VF) mutation increases cardiovascular risk …
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis
Receptor-interacting protein kinase 3 (RIP3)-regulated production of reactive oxygen
species (ROS) positively feeds back on tumour necrosis factor (TNF)-induced necroptosis, a …
species (ROS) positively feeds back on tumour necrosis factor (TNF)-induced necroptosis, a …