The receptor-interacting protein kinase 3 (RIP3/RIPK3) has emerged as a critical regulator of
programmed necrosis/necroptosis, an inflammatory form of cell death with important …

During atherosclerosis, lipid-rich plaques are formed in large-and medium-sized arteries,
which can reduce blood flow to tissues. This situation becomes particularly precarious when …

Atherosclerosis is characterized by the retention of modified lipoproteins in the arterial wall.
These modified lipoproteins activate resident macrophages and the recruitment of monocyte …

Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …

Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …

Necroptosis is mediated by a signaling complex called necrosome, containing receptor-
interacting protein (RIP) 1, RIP3, and mixed-lineage kinase domain-like (MLKL). It is known …

Innate immunity represents the first line of defence against invading pathogens. It consists of
an initial inflammatory response that recruits white blood cells to the site of infection in an …

Atherothrombotic vascular disease is often triggered by a distinct type of atherosclerotic
lesion that displays features of impaired inflammation resolution, notably a necrotic core and …

Arterial inflammation is a hallmark of atherosclerosis, and appropriate management of this
inflammation represents a major unmet therapeutic need for cardiovascular disease …

Perinatal insults such as hypoxia–ischemia induces secondary brain injury. In order to
develop the next generation of neuroprotective therapies, we urgently need to understand …