A newly discovered mechanism of cell death, programmed necrosis (necroptosis), combines
features of both necrosis and apoptosis. Necroptosis is tightly modulated by a series of …

Necroptosis is a type of regulated cell death dependent on the activity of receptor-interacting
serine/threonine-protein (RIP) kinases. However, unlike apoptosis, it is caspase …

Abstract Gaucher's disease (GD), an inherited metabolic disorder caused by mutations in the
glucocerebrosidase gene (GBA), is the most common lysosomal storage disease …

Transplantation is invariably associated with ischemia–reperfusion injury (IRI), inflammation
and rejection. Resultant cell death has morphological features of necrosis but programmed …

Objective: Inflammatory activation changes the mitochondrial function of macrophages from
oxidative phosphorylation to reactive oxygen species production, which may promote …

Necroptosis was initially identified as a backup cell death program when apoptosis is
blocked. However, it is now recognized as a cellular defense mechanism against infections …

Apoptosis, necrosis and autophagy-dependent cell death are the three major types of cell
death. Traditionally, necrosis is thought as a passive and unregulated form of cell death …

Oligomerization of the mixed-lineage kinase domain-like protein (MLKL) is essential for its
cation channel function in necroptosis. Here we show that the MLKL channel is an octamer …

Atherosclerosis is a progressive inflammatory disorder of the arterial vessel wall
characterized by substantial infiltration of macrophages, which exert both favourable and …

Defective inflammation resolution is the underlying cause of prevalent chronic inflammatory
diseases, such as arthritis, asthma, cancer, and neurodegenerative and cardiovascular …