Abstract The United States Food and Drug Administration (US FDA) has always been a
forerunner in drug evaluation and supervision. Over the past 31 years, 1050 drugs …

Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Context.—In 2013, an evidence-based guideline was published by the College of American
Pathologists, the International Association for the Study of Lung Cancer, and the Association …

Purpose: The third-generation EGFR tyrosine kinase inhibitor osimertinib is approved to
treat patients with EGFR T790M-positive non–small cell lung cancer (NSCLC) who have …

Background We aimed to assess the effect of afatinib on overall survival of patients with
EGFR mutation-positive lung adenocarcinoma through an analysis of data from two open …

Background Most patients with non-small-cell lung cancer tumours that have EGFR
mutations have deletion mutations in exon 19 or the Leu858Arg point mutation in exon 21 …

Purpose: Tumor mutation burden (TMB) is a biomarker of response to immune checkpoint
blockade (ICB). The impact of TMB on outcomes with targeted therapies has not been …

Background Although EGFR mutant tumors exhibit low response rates to immune
checkpoint blockade overall, some EGFR mutant tumors do respond to these therapies; …

Lung cancer is the leading cause of cancer-related deaths worldwide. It exhibits, at the
mesoscopic scale, phenotypic characteristics that are generally indiscernible to the human …

Salicylic acid (SA) is an important phytohormone mediating both local and systemic defense
responses in plants. Despite over half a century of research, how plants biosynthesize SA …