The residual risk for arteriosclerotic cardiovascular disease after optimal statin treatment
may amount to 50% and is the consequence of both immunological and lipid disturbances …

Despite the best pharmacologic tools available, cardiovascular diseases (CVDs) remain a
major cause of morbidity and mortality in developed countries. After 2 decades of research …

Since statins have had such tremendous therapeutic success over the last three decades,
the field of atherosclerosis has become somewhat LDL-centric, dismissing the relevance of …

Background Ectopic lipid deposition plays a promoting role in many chronic metabolic
diseases. Abnormal adipogenic differentiation of mesenchymal stem cells (MSCs) is an …

Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in
liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by …

Background: T-cell death-associated gene 51 (TDAG51) belongs to the transcription factor
family and is involved in the energy homeostasis of the liver through the regulation of …

Context Nonalcoholic fatty liver disease (NAFLD) is a metabolical disorder and can lead to
liver fibrosis. Because it is commonly seen, several noninvasive scores (NS) have been …

The availability of sugar has expanded over the past 50 years, due to improved industrial
processes and corn subsidies, particularly in the form of sweetened beverages. This …

Liver injury is closely related to poor outcomes in sepsis patients. Current studies indicate
that sepsis is accompanied by metabolic disorders, especially those related to lipid …

Angiopoietin-like protein 8 (ANGPTL8) is an hepatokine altered in several metabolic
conditions, such as obesity, type 2 diabetes, dyslipidemia and nonalcoholic fatty liver …