Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Klebsiella pneumoniae carbapenemase (KPC) variants, which refer to the substitution,
insertion, or deletion of amino acid sequence compared to wild bla KPC type, have reduced …

In recent years, traditional antibiotic efficacy has rapidly diminished due to the advent of
multidrug‐resistant (MDR) bacteria, which poses severe threat to human life and globalized …

Colistin is regarded as a last-line drug against serious infections caused by multidrug-
resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin …

Lipopeptides are amphiphilic peptides in which an aliphatic chain is attached to either the C
or N terminus of peptides. Their self-assembly—into micelles, vesicles, nanotubes, fibres or …

The emergence of multidrug-resistant (MDR) Gram-negative pathogens is an urgent global
medical challenge. The old polymyxin lipopeptide antibiotics (polymyxin B and colistin) are …

Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAb) is 1 of the
most problematic antimicrobial-resistant bacteria. We sought to elucidate the international …

Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of
mortality and morbidity across the world. Indiscriminate use of broad-spectrum antibiotics …

Bacterial infections pose a significant threat to human health and a heavy burden on the
global healthcare system. Antibiotics are the primary treatment, but they can lead to bacterial …

Antimicrobial resistance is a global public health threat, and the World Health Organization
(WHO) has announced a priority list of the most threatening pathogens against which novel …