Therapeutical growth in oligodendroglial fate induction via transdifferentiation of stem cells for neuroregenerative therapy

S Dwivedi, P Choudhary, A Gupta, S Singh - Biochimie, 2023 - Elsevier
The merits of stem cell therapy and research are undisputed due to their widespread usage
in the treatment of neurodegenerative diseases and demyelinating disorders. Cell …

Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis

BL Marques, GF Maciel, MRB Júnior, LD Dias… - Seminars in Cell & …, 2023 - Elsevier
The world population's life expectancy is growing, and neurodegenerative disorders
common in old age require more efficient therapies. In this context, neural stem cells (NSCs) …

[HTML][HTML] rAAV2-Mediated restoration of GALC in neural stem cells from Krabbe patient-derived iPSCs

G Tian, C Cao, S Li, W Wang, Y Zhang, Y Lv - Pharmaceuticals, 2023 - mdpi.com
Krabbe disease is a rare neurodegenerative fatal disease. It is caused by deficiency of the
lysosomal enzyme galactocerebrosidase (GALC), which results in progressive accumulation …

Stem cells therapeutic effect in a reserpine-induced fibromyalgia rat model: A possible NLRP3 inflammasome modulation with neurogenesis promotion in the cerebral …

SA Mokhemer, MK Desouky, AK Abdelghany… - Life Sciences, 2023 - Elsevier
Fibromyalgia is a chronic pain syndrome with a multifactorial pathophysiology affecting 2–
8% of the population. Aims To investigate the therapeutic effects of bone marrow …

[HTML][HTML] The Intricate Epigenetic and Transcriptional Alterations in Pediatric High-Grade Gliomas: Targeting the Crosstalk as the Oncogenic Achilles' Heel

P Huchedé, P Leblond, M Castets - Biomedicines, 2022 - mdpi.com
Pediatric high-grade gliomas (pHGGs) are a deadly and heterogenous subgroup of gliomas
for which the development of innovative treatments is urgent. Advances in high-throughput …

Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells

MM Chang, YK Hong, CK Hsu, HIC Harn… - Stem cells …, 2024 - academic.oup.com
Human adipose-derived stem cells (ASCs) have shown immense potential for regenerative
medicine. Our previous work demonstrated that chitosan nano-deposited surfaces induce …

Electroconductive Collagen‐Carbon Nanodots Nanocomposite Elicits Neurite Outgrowth, Supports Neurogenic Differentiation and Accelerates Electrophysiological …

DJ Lomboni, A Ozgun, TV de Medeiros… - Advanced …, 2024 - Wiley Online Library
Neuronal disorders are characterized by the loss of functional neurons and disrupted
neuroanatomical connectivity, severely impacting the quality of life of patients. This study …

[HTML][HTML] Characterization of neural stem cells derived from human stem cells from the apical papilla undergoing three-dimensional neurosphere induction

AT Songsaad, S Thairat, P Seemaung… - Journal of Applied Oral …, 2023 - SciELO Brasil
Objectives The endogenous repairing based on the activation of neural stem cells (NSCs) is
impaired by neurodegenerative diseases. The present study aims to characterize human …

[HTML][HTML] In Vitro Simulated Neuronal Environmental Conditions Qualify Umbilical Cord Derived Highly Potent Stem Cells for Neuronal Differentiation

J Maassen, R Guenther, TJJ Hondrich… - Stem cell reviews and …, 2023 - Springer
The healing of neuronal injuries is still an unachieved goal. Medicine-based therapies can
only extend the survival of patients, but not finally lead to a healing process. Currently, a …

Using human fetal neural stem cells to elucidate the role of the JAK-STAT cell signaling pathway in oligodendrocyte differentiation in vitro

D Dey, S Tyagi, V Shrivastava, S Rani, JB Sharma… - Molecular …, 2024 - Springer
Oligodendrocytes (OL) are the myelinating cells of the central nervous system that mediate
nerve conduction. Loss of oligodendrocytes results in demyelination, triggering neurological …