Therapeutical growth in oligodendroglial fate induction via transdifferentiation of stem cells for neuroregenerative therapy
The merits of stem cell therapy and research are undisputed due to their widespread usage
in the treatment of neurodegenerative diseases and demyelinating disorders. Cell …
in the treatment of neurodegenerative diseases and demyelinating disorders. Cell …
Regulatory mechanisms of stem cell differentiation: Biotechnological applications for neurogenesis
BL Marques, GF Maciel, MRB Júnior, LD Dias… - Seminars in Cell & …, 2023 - Elsevier
The world population's life expectancy is growing, and neurodegenerative disorders
common in old age require more efficient therapies. In this context, neural stem cells (NSCs) …
common in old age require more efficient therapies. In this context, neural stem cells (NSCs) …
[HTML][HTML] rAAV2-Mediated restoration of GALC in neural stem cells from Krabbe patient-derived iPSCs
G Tian, C Cao, S Li, W Wang, Y Zhang, Y Lv - Pharmaceuticals, 2023 - mdpi.com
Krabbe disease is a rare neurodegenerative fatal disease. It is caused by deficiency of the
lysosomal enzyme galactocerebrosidase (GALC), which results in progressive accumulation …
lysosomal enzyme galactocerebrosidase (GALC), which results in progressive accumulation …
Stem cells therapeutic effect in a reserpine-induced fibromyalgia rat model: A possible NLRP3 inflammasome modulation with neurogenesis promotion in the cerebral …
Fibromyalgia is a chronic pain syndrome with a multifactorial pathophysiology affecting 2–
8% of the population. Aims To investigate the therapeutic effects of bone marrow …
8% of the population. Aims To investigate the therapeutic effects of bone marrow …
[HTML][HTML] The Intricate Epigenetic and Transcriptional Alterations in Pediatric High-Grade Gliomas: Targeting the Crosstalk as the Oncogenic Achilles' Heel
P Huchedé, P Leblond, M Castets - Biomedicines, 2022 - mdpi.com
Pediatric high-grade gliomas (pHGGs) are a deadly and heterogenous subgroup of gliomas
for which the development of innovative treatments is urgent. Advances in high-throughput …
for which the development of innovative treatments is urgent. Advances in high-throughput …
Histone Trimethylations and HDAC5 Regulate Spheroid Subpopulation and Differentiation Signaling of Human Adipose-Derived Stem Cells
Human adipose-derived stem cells (ASCs) have shown immense potential for regenerative
medicine. Our previous work demonstrated that chitosan nano-deposited surfaces induce …
medicine. Our previous work demonstrated that chitosan nano-deposited surfaces induce …
Electroconductive Collagen‐Carbon Nanodots Nanocomposite Elicits Neurite Outgrowth, Supports Neurogenic Differentiation and Accelerates Electrophysiological …
DJ Lomboni, A Ozgun, TV de Medeiros… - Advanced …, 2024 - Wiley Online Library
Neuronal disorders are characterized by the loss of functional neurons and disrupted
neuroanatomical connectivity, severely impacting the quality of life of patients. This study …
neuroanatomical connectivity, severely impacting the quality of life of patients. This study …
[HTML][HTML] Characterization of neural stem cells derived from human stem cells from the apical papilla undergoing three-dimensional neurosphere induction
AT Songsaad, S Thairat, P Seemaung… - Journal of Applied Oral …, 2023 - SciELO Brasil
Objectives The endogenous repairing based on the activation of neural stem cells (NSCs) is
impaired by neurodegenerative diseases. The present study aims to characterize human …
impaired by neurodegenerative diseases. The present study aims to characterize human …
[HTML][HTML] In Vitro Simulated Neuronal Environmental Conditions Qualify Umbilical Cord Derived Highly Potent Stem Cells for Neuronal Differentiation
J Maassen, R Guenther, TJJ Hondrich… - Stem cell reviews and …, 2023 - Springer
The healing of neuronal injuries is still an unachieved goal. Medicine-based therapies can
only extend the survival of patients, but not finally lead to a healing process. Currently, a …
only extend the survival of patients, but not finally lead to a healing process. Currently, a …
Using human fetal neural stem cells to elucidate the role of the JAK-STAT cell signaling pathway in oligodendrocyte differentiation in vitro
D Dey, S Tyagi, V Shrivastava, S Rani, JB Sharma… - Molecular …, 2024 - Springer
Oligodendrocytes (OL) are the myelinating cells of the central nervous system that mediate
nerve conduction. Loss of oligodendrocytes results in demyelination, triggering neurological …
nerve conduction. Loss of oligodendrocytes results in demyelination, triggering neurological …