Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and
antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers …

Over expression of B7-H1 (also named PDL-1 or CD 274) molecule in cancer has been
linked to worse prognosis and resistance to anti-cancer therapies in several malignancies …

Background Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the formation
of prostaglandins. The inducible isoform of COX (COX-2) is highly expressed in aggressive …

In cystic fibrosis (CF) patients, hyper-inflammation is a key factor in lung destruction and
disease morbidity. We have previously demonstrated that macrophages drive the lung hyper …

Lung cancer is one of the most common cancers in the population and is characterized by
non-specific symptoms that delay the diagnosis and reduce the effectiveness of oncological …

Nimesulide is a nonsteroidal anti-inflammatory drug possessing analgesic and antipyretic
properties. This drug is considered a selective cyclooxygenase-2 (COX-2) inhibitor and …

Phellodendron amurense extract is a Chinese herbal remedy that has recently been studied
for its antitumor, antimicrobial and other biological activities. It is previously unknown if these …

Abstract Background Prostaglandin E 2 (PGE 2), an arachidonic acid metabolite converted
by cyclooxygenase-2 (COX-2), plays important roles in the regulation of endothelial …

Coumarins have attracted intense interest in recent years because they have been identified
from natural sources, especially green plants and have diverse pharmacological properties …

Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of
cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead …