Research on the use of biodegradable polymers for drug delivery has been ongoing since
they were first used as bioresorbable surgical devices in the 1980s. For tissue engineering …

Lung cancer is the deadliest cancer worldwide. Tissue biopsy is currently employed for the
diagnosis and molecular stratification of lung cancer. Liquid biopsy is a minimally invasive …

The cytotoxic anti-cancer drugs cisplatin, paclitaxel, doxorubicin, 5-fluorouracil (5-FU), as
well as targeted drugs including imatinib, erlotinib, and nivolumab, play key roles in clinical …

Background Several mechanisms including abnormal activation of PI3K-AKT-mTOR
pathway have been proved to generate acquired resistance to epidermal growth factor …

Despite a well-established role for the epidermal growth factor receptor (EGFR) in
tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We …

Almost all clinical oncologists agree that the discovery of reliable, accessible, and non-
invasive biomarkers is necessary to decrease cancer mortality. It is possible to employ …

Secondary mutation, T790M, conferring tyrosine kinase inhibitors (TKIs) resistance beyond
oncogenic epidermal growth factor receptor (EGFR) mutations presents a challenging unmet …

Abstract Background Circular RNAs (circRNAs) are a new class of endogenous non-coding
RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has highlighted …

All lung cancers patients with epidermal growth factor receptor (EGFR) mutation inevitably
develop acquired resistance to EGFR tyrosine kinase inhibitors (TKI). In up to 30% of cases …

Gefitinib is suitable for the treatment of locally advanced or metastatic non–small cell lung
cancer. However, the development of acquired resistance limits its long-term efficacy in …