Computational models for predicting substrates or inhibitors of P-glycoprotein
L Chen, Y Li, H Yu, L Zhang, T Hou - Drug discovery today, 2012 - Elsevier
The impact of P-glycoprotein (P-gp) on the multidrug resistance and pharmacokinetics of
clinically important drugs has been widely recognized. Here, we review in silico approaches …
clinically important drugs has been widely recognized. Here, we review in silico approaches …
MDR1 genotype-related pharmacokinetics: fact or fiction?
T Sakaeda - Drug metabolism and pharmacokinetics, 2005 - jstage.jst.go.jp
Multidrug resistant transporter MDR1WP-glycoprotein, the gene product of MDR1, is a
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette …
[HTML][HTML] Common genetic variants and pathways in diabetes and associated complications and vulnerability of populations with different ethnic origins
Diabetes mellitus is a complex and heterogeneous metabolic disorder which is often pre-or
post-existent with complications such as cardiovascular disease, hypertension …
post-existent with complications such as cardiovascular disease, hypertension …
MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer
The drug efflux function of P-glycoprotein (P-gp) encoded by MDR1 can be influenced by
genetic polymorphisms, including two synonymous changes in the coding region of MDR1 …
genetic polymorphisms, including two synonymous changes in the coding region of MDR1 …
The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition
Significant intra-and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by …
mdr-1 Single Nucleotide Polymorphisms in Ovarian Cancer Tissue: G2677T/A Correlates with Response to Paclitaxel Chemotherapy
H Green, P Söderkvist, P Rosenberg, G Horvath… - Clinical Cancer …, 2006 - AACR
Purpose: P-glycoprotein, encoded by the mdr-1 gene, confers multidrug resistance to a
variety of antineoplastic agents, eg, paclitaxel. Recently, different polymorphisms in the mdr …
variety of antineoplastic agents, eg, paclitaxel. Recently, different polymorphisms in the mdr …
Transport proteins of the ABC family and multidrug resistance of tumor cells
AA Stavrovskaya, TP Stromskaya - Biochemistry (Moscow), 2008 - Springer
Some new data concerning the role of transport proteins of the ABC family in multidrug
resistance (MDR) of human tumor cells, and problems connected with regulation of these …
resistance (MDR) of human tumor cells, and problems connected with regulation of these …
CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation
A Capron, M Mourad, M De Meyer, L De Pauw… - …, 2010 - Future Medicine
Aims: This prospective study investigated the effect of genetic polymorphisms in a
biotransformation enzyme (CYP3A5) and a transporter protein (ABCB1) on tacrolimus (Tac) …
biotransformation enzyme (CYP3A5) and a transporter protein (ABCB1) on tacrolimus (Tac) …
Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1
S Ozawa, A Soyama, M Saeki… - Drug metabolism and …, 2004 - jstage.jst.go.jp
Metabolic capacities for debrisoquin, sparteine, mephenytoin, nifedipine, and midazolam,
which are substrates of polymorphic CYP2D6, CYP2C19, and CYP3A, have been reported …
which are substrates of polymorphic CYP2D6, CYP2C19, and CYP3A, have been reported …
Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer
TM Bosch, I Meijerman, JH Beijnen… - Clinical …, 2006 - Springer
There is wide variability in the response of individuals to standard doses of drug therapy.
This is an important problem in clinical practice, where it can lead to therapeutic failures or …
This is an important problem in clinical practice, where it can lead to therapeutic failures or …